InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADSSL1

Summary

InnateDB Protein

IDBP-22616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADSSL1

Protein Name

adenylosuccinate synthase like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000331260

InnateDB Gene

IDBG-22614 (ADSSL1)

Protein Structure

UniProt Annotation

Function

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03126, ECO:0000269PubMed:15786719}.

Disease Associations

Tissue Specificity

Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. {ECO:0000269PubMed:15786719}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004019	adenylosuccinate synthase activity
GO:0005525	GTP binding
GO:0042301	phosphate ion binding

Biological Process

GO:0002376	immune system process
GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0044208	'de novo' AMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process