InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADSSL1

Summary

InnateDB Gene

IDBG-22614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADSSL1

Gene Name

adenylosuccinate synthase like 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000185100

Encoded Proteins

IDBP-22616

adenylosuccinate synthase like 1

IDBP-22618

adenylosuccinate synthase like 1

IDBP-808868

adenylosuccinate synthase like 1

IDBP-602141

adenylosuccinate synthase like 1

IDBP-585978

adenylosuccinate synthase like 1

IDBP-584202

adenylosuccinate synthase like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC 6.3.4.4), which catalyzes the initial reaction in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al., 2005 [PubMed 15786719]).[supplied by OMIM, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:104724186-104747325

Strand

Forward strand

Band

q32.33

Transcripts

ENST00000330877	ENSP00000331260
ENST00000332972	ENSP00000333019
ENST00000555486	ENSP00000473778
ENST00000553540	ENSP00000450759
ENST00000557582
ENST00000554281
ENST00000553580
ENST00000555884
ENST00000557271
ENST00000554657
ENST00000556623	ENSP00000452303
ENST00000555674	ENSP00000450433

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003924	GTPase activity
GO:0004019	adenylosuccinate synthase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042301	phosphate ion binding
GO:0042803	protein homodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0002376	immune system process
GO:0006144	purine nucleobase metabolic process
GO:0006163	purine nucleotide metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0006184	GTP catabolic process
GO:0006531	aspartate metabolic process
GO:0006541	glutamine metabolic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0014850	response to muscle activity
GO:0035690	cellular response to drug
GO:0042594	response to starvation
GO:0044208	'de novo' AMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046040	IMP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000011148

View Gene Order

ENSBTAG00000017616

Not yet available

Pathways

NETPATH

REACTOME

REACT_1776

Purine ribonucleoside monophosphate biosynthesis pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_522

Purine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

hsa00250

Alanine, aspartate and glutamate metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Alanine Aspartate Asparagine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

G3V232

UniProt Splice Variant

Entrez Gene

122622

UniGene

Hs.375179 Hs.592327

RefSeq

NM_152328 NM_199165 XM_006720026

HUGO

HGNC:20093

OMIM

612498

CCDS

CCDS9990 CCDS9991

HPRD

12433

IMGT

EMBL

AL583722

GenPept

RNA Seq Atlas

122622