InnateDB Protein
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IDBP-22618.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ADSSL1
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Protein Name
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adenylosuccinate synthase like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333019
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InnateDB Gene
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IDBG-22614 (ADSSL1)
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Protein Structure
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Function |
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03126, ECO:0000269PubMed:15786719}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. {ECO:0000269PubMed:15786719}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001114
Adenylosuccinate synthetase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00709
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PRINTS |
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PIRSF |
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SMART |
SM00788
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N142
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PhosphoSite |
PhosphoSite-Q8N142
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TrEMBL |
G3V5D8
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UniProt Splice Variant |
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Entrez Gene |
122622
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UniGene |
Hs.592327
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RefSeq |
NP_954634
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HUGO |
HGNC:20093
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OMIM |
612498
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CCDS |
CCDS9991
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HPRD |
12433
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IMGT |
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EMBL |
AK095921
AK096124
AK096720
AL583722
AY037159
BC032039
BC047904
BX248286
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GenPept |
AAH32039
AAH47904
AAK67646
BAC04649
BAG53216
BAG53356
CAD62614
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