InnateDB Protein
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IDBP-226766.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MIER1
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Protein Name
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mesoderm induction early response 1 homolog (Xenopus laevis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383820
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InnateDB Gene
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IDBG-99523 (MIER1)
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Protein Structure
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Function |
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269PubMed:12482978}.
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Subcellular Localization |
Isoform 1: Nucleus.Isoform 2: Nucleus.Isoform 3: Nucleus.Isoform 4: Cytoplasm.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. {ECO:0000269PubMed:12242014, ECO:0000269PubMed:9813250}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000949
ELM2 domain
IPR001005
SANT/Myb domain
IPR009057
Homeodomain-like
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PFAM |
PF01448
PF00249
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PRINTS |
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PIRSF |
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SMART |
SM00717
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N108
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PhosphoSite |
PhosphoSite-Q8N108
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57708
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UniGene |
Hs.709000
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RefSeq |
NP_001071168
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HUGO |
HGNC:29657
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OMIM |
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CCDS |
CCDS53326
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HPRD |
11362
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IMGT |
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EMBL |
AB046830
AF515446
AF515447
AF515448
AK074990
AK302061
AL139216
AL500525
AL831987
AY124186
AY124187
AY124188
AY124189
AY124190
AY124191
AY124192
AY124193
AY124194
BC017423
BC108726
BC125217
BC125218
CH471059
CR627441
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GenPept |
AAH17423
AAI08727
AAI25218
AAI25219
AAM76040
AAM76041
AAM76042
AAM97499
AAM97500
AAM97501
AAM97502
AAM97503
AAM97504
AAM97505
AAM97506
AAM97507
BAB13436
BAC11339
BAG63451
CAD89921
CAH10526
CAI18873
CAI18874
CAI18875
CAI18876
CAI18878
CAI18879
CAI23427
CAI23428
CAI23429
CAI23430
CAI23431
CAI23432
EAX06505
EAX06508
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