InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF18

Summary

InnateDB Protein

IDBP-22693.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF18

Protein Name

Rho/Rac guanine nucleotide exchange factor (GEF) 18

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319200

InnateDB Gene

IDBG-22691 (ARHGEF18)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. {ECO:0000269PubMed:11085924, ECO:0000269PubMed:14512443, ECO:0000269PubMed:15558029}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15558029}. Note=Colocalizes with actin stress fibers.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. {ECO:0000269PubMed:11085924, ECO:0000269PubMed:14512443, ECO:0000269PubMed:15558029}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway