InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR6

Summary

InnateDB Protein

IDBP-227075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR6

Protein Name

chemokine (C-C motif) receptor 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383715

InnateDB Gene

IDBG-99015 (CCR6)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. {ECO:0000269PubMed:9169459}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005249	voltage-gated potassium channel activity
GO:0016493	C-C chemokine receptor activity
GO:0050825	ice binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006813	potassium ion transport
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0042309	homoiothermy
GO:0045087	innate immune response (InnateDB)
GO:0050826	response to freezing
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR004067 CC chemokine receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00427
PR00237
PR00657
PR00645
PR01529

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51684