InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCR6

Summary

InnateDB Gene

IDBG-99015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR6

Gene Name

chemokine (C-C motif) receptor 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112486

Encoded Proteins

IDBP-99023

chemokine (C-C motif) receptor 6

IDBP-99025

chemokine (C-C motif) receptor 6

IDBP-227075

chemokine (C-C motif) receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21042003

CCR6 mobilizes TCR-alpha/beta+, CCR6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. CCR6 is not required for induction of the adaptive antimycobacterial response

PMID 21376174

CCR6 is a chemokine receptor that only binds to a single chemokine ligand, CCL20. CCR6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 21042003

[Mus musculus] Ccr6 mobilizes TCR-alpha/beta+, Ccr6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. Ccr6 is not required for induction of the adaptive antimycobacterial response

PMID 21376174

[Mus musculus] Ccr6 is a chemokine receptor that only binds to a single chemokine ligand, Ccl20. Ccr6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.

Entrez Gene

Summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:167122769-167139696

Strand

Forward strand

Band

q27

Transcripts

ENST00000341935	ENSP00000343952
ENST00000349984	ENSP00000339393
ENST00000400926	ENSP00000383715

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway