InnateDB Protein
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IDBP-22708.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SDCBP
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Protein Name
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syndecan binding protein (syntenin)
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Synonyms
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MDA-9; MDA9; ST1; SYCL; TACIP18;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260130
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InnateDB Gene
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IDBG-22706 (SDCBP)
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Protein Structure
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Function |
Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. {ECO:0000269PubMed:10230395, ECO:0000269PubMed:11179419, ECO:0000269PubMed:11498591}.
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Subcellular Localization |
Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
53
[view]
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Protein-Protein |
53
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
O00560
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PhosphoSite |
PhosphoSite-O00560
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TrEMBL |
A0A024R7Z5
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UniProt Splice Variant |
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Entrez Gene |
6386
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UniGene |
Hs.200804
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RefSeq |
NP_005616
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HUGO |
HGNC:10662
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OMIM |
602217
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CCDS |
CCDS6172
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HPRD |
03741
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IMGT |
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EMBL |
AC068522
AF000652
AF006636
AK300647
AK312274
BC113674
BC113676
BC143915
BC143916
CH471068
U83463
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GenPept |
AAB51246
AAB97144
AAC52050
AAI13675
AAI13677
AAI43916
AAI43917
BAG35204
BAG62335
EAW86814
EAW86815
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