InnateDB Protein
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IDBP-22722.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IAPP
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Protein Name
|
islet amyloid polypeptide
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Synonyms
|
DAP; IAP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000240652
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InnateDB Gene
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IDBG-22720 (IAPP)
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Protein Structure
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|
Function |
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:17374526}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000443
Pro-islet amyloid polypeptide
IPR001693
Calcitonin peptide-like
IPR021116
Procalcitonin/adrenomedullin
|
PFAM |
PF00214
|
PRINTS |
PR00818
|
PIRSF |
|
SMART |
SM00113
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TIGRFAMs |
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Modification |
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SwissProt |
P10997
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PhosphoSite |
PhosphoSite-P10997
|
TrEMBL |
F5H0S1
|
UniProt Splice Variant |
|
Entrez Gene |
3375
|
UniGene |
Hs.707796
|
RefSeq |
NP_000406
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HUGO |
HGNC:5329
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OMIM |
147940
|
CCDS |
CCDS8688
|
HPRD |
01005
|
IMGT |
|
EMBL |
AC006559
AC022224
CH471094
DQ516082
J04422
M21785
M26650
M27503
X13859
X14902
X14903
X14904
X14905
X52818
X52819
X55634
X56030
X68830
|
GenPept |
AAA35524
AAA35983
AAA51728
AAA52281
ABG27010
CAA33031
CAA33032
CAA33033
CAA37002
CAA39504
CAA48724
CAB57803
CAB57804
EAW96426
EAW96427
|
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