InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IAPP

Summary

InnateDB Gene

IDBG-22720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IAPP

Gene Name

islet amyloid polypeptide

Synonyms

DAP; IAP

Species

Homo sapiens

Ensembl Gene

ENSG00000121351

Encoded Proteins

IDBP-22722

islet amyloid polypeptide

IDBP-584584

islet amyloid polypeptide

IDBP-596151

islet amyloid polypeptide

IDBP-586269

islet amyloid polypeptide

IDBP-598364

islet amyloid polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer\'s disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:21354959-21379978

Strand

Forward strand

Band

p12.1

Transcripts

ENST00000240652	ENSP00000240652
ENST00000539393	ENSP00000437357
ENST00000542023	ENSP00000445711
ENST00000537593	ENSP00000445980
ENST00000535428	ENSP00000437559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0042802	identical protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0019233	sensory perception of pain
GO:0031018	endocrine pancreas development
GO:0042755	eating behavior
GO:0045596	negative regulation of cell differentiation
GO:0045779	negative regulation of bone resorption