Version 5.4
Homo sapiens Protein: CCNL2
Summary
InnateDB Protein IDBP-227362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNL2
Protein Name cyclin L2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383611
InnateDB Gene IDBG-281455 (CCNL2)
Protein Structure
UniProt Annotation
Function Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis. {ECO:0000269PubMed:14684736}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:14684736}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and pancreas. {ECO:0000269PubMed:14684736}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR004367 Cyclin, C-terminal domain
IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
IPR017060 Cyclin L
PFAM PF02984
PF00134
PRINTS
PIRSF PIRSF036580
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96S94
PhosphoSite PhosphoSite-Q96S94
TrEMBL J3QSH2
UniProt Splice Variant
Entrez Gene 81669
UniGene Hs.735359
RefSeq NP_112199
HUGO HGNC:20570
OMIM 613482
CCDS CCDS30557
HPRD 10815
IMGT
EMBL AF087903 AK027770 AK074112 AK292268 AK293451 AL391244 AL834432 AL834441 AY037150 AY116620 BC016333 BC071622 CH471183 CR628411
GenPept AAH16333 AAH71622 AAK67631 AAM76789 AAP97201 BAB84938 BAF84957 BAG51376 BAG56949 CAD39092 CAD39101 CAI22659 CAI22660 CAM12829 EAW56213 EAW56215 EAW56216 EAW56217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca