Version 5.4
Homo sapiens Gene: CCNL2
Summary
InnateDB Gene IDBG-281455.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNL2
Gene Name cyclin L2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000221978
Encoded Proteins
IDBP-227362
cyclin L2
IDBP-292364
cyclin L2
IDBP-292365
cyclin L2
IDBP-361569
cyclin L2
IDBP-721879
IDBP-479900
cyclin L2
IDBP-480897
cyclin L2
IDBP-722188
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1385711-1399338
Strand Reverse strand
Band p36.33
Transcripts
ENST00000400809 ENSP00000383611
ENST00000408952 ENSP00000386132
ENST00000408918 ENSP00000386158
ENST00000418865
ENST00000425598 ENSP00000392899
ENST00000480479
ENST00000482621 ENSP00000462056
ENST00000463260
ENST00000496007
ENST00000482365
ENST00000481223 ENSP00000423734
ENST00000505849
ENST00000488340 ENSP00000424647
ENST00000492998
ENST00000469113
ENST00000480646
ENST00000471930
ENST00000473872
ENST00000463895
ENST00000497013 ENSP00000464685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029068
View Gene Order
ENSBTAG00000004873
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515704 Hs.678050 Hs.708906 Hs.735359
RefSeq NM_001039577 NM_030937 XM_006710933 XM_006710934
HUGO
OMIM
CCDS CCDS30557 CCDS30558
HPRD 10815
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca