Version 5.4
Homo sapiens Protein: HSF1
Summary
InnateDB Protein IDBP-227438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSF1
Protein Name heat shock transcription factor 1
Synonyms HSTF1;
Species Homo sapiens
Ensembl Protein ENSP00000383590
InnateDB Gene IDBG-40498 (HSF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 122 [view]
Protein-Protein 115 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009408 response to heat
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
PFAM PF00447
PF06546
PRINTS PR00056
PIRSF
SMART SM00415
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PMQ6
UniProt Splice Variant
Entrez Gene 3297
UniGene Hs.530227
RefSeq XP_005272372
HUGO HGNC:5224
OMIM 140580
CCDS
HPRD 00778
IMGT
EMBL AC110280 AF205589
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca