Version 5.4
Homo sapiens Gene: HSF1
Summary
InnateDB Gene IDBG-40498.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSF1
Gene Name heat shock transcription factor 1
Synonyms HSTF1
Species Homo sapiens
Ensembl Gene ENSG00000185122
Encoded Proteins
IDBP-227438
heat shock transcription factor 1
IDBP-600409
heat shock transcription factor 1
IDBP-809917
heat shock transcription factor 1
IDBP-587293
heat shock transcription factor 1
IDBP-809929
heat shock transcription factor 1
IDBP-809938
heat shock transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20018623
HSF1 activated by heat shock induces the expression of ATF3, a negative regulator of IL-6, and ATF3 is necessary for heat-mediated suppression of IL-6, indicating a fever-mediated feedback loop consisting of HSF1 and ATF3.
PMID 22042134
HSF1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through TLR2 signalling activation. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22042134
[Mus musculus] Hsf1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through Tlr2 signalling activation.
Entrez Gene
Summary The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144291591-144314722
Strand Forward strand
Band q24.3
Transcripts
ENST00000400780 ENSP00000383590
ENST00000528838 ENSP00000431512
ENST00000528988 ENSP00000481007
ENST00000533240 ENSP00000436616
ENST00000532338
ENST00000528199
ENST00000529630
ENST00000534314 ENSP00000484174
ENST00000527328
ENST00000531447
ENST00000533130
ENST00000530661 ENSP00000480423
ENST00000528842
ENST00000614796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 122 [view]
Protein-Protein 115 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006952 defense response
GO:0007143 female meiotic division
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell proliferation
GO:0009408 response to heat
GO:0032496 response to lipopolysaccharide
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034605 cellular response to heat
GO:0040018 positive regulation of multicellular organism growth
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060136 embryonic process involved in female pregnancy
GO:0090231 regulation of spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
GO:0045120 pronucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022556
View Gene Order
ENSBTAG00000020751
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_200624
Attenuation phase pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_200744
HSF1 activation pathway
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.530227
RefSeq NM_005526
HUGO
OMIM
CCDS CCDS6419
HPRD 00778
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca