Version 5.4
Homo sapiens Protein: PPP4R1
Summary
InnateDB Protein IDBP-227939.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4R1
Protein Name protein phosphatase 4, regulatory subunit 1
Synonyms MEG1; PP4(Rmeg); PP4R1;
Species Homo sapiens
Ensembl Protein ENSP00000383401
InnateDB Gene IDBG-812 (PPP4R1)
Protein Structure
UniProt Annotation
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. {ECO:0000269PubMed:15805470}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues. {ECO:0000269PubMed:11729228}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0030362 protein phosphatase type 4 regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016311 dephosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0030289 protein phosphatase 4 complex
Protein Structure and Domains
PDB ID
InterPro IPR000357 HEAT
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
PFAM PF02985
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF05
PhosphoSite PhosphoSite-Q8TF05
TrEMBL J3QLA6
UniProt Splice Variant
Entrez Gene 9989
UniGene Hs.743236
RefSeq NP_005125
HUGO HGNC:9320
OMIM 604908
CCDS CCDS42413
HPRD
IMGT
EMBL AF100744 AF111106 AF200478 AK295533 AP000902 AP001381 BC060829 U79267
GenPept AAB50211 AAD09818 AAD43008 AAH60829 AAL78298 BAG58445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca