InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXNRD2

Summary

InnateDB Protein

IDBP-228026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNRD2

Protein Name

thioredoxin reductase 2

Synonyms

SELZ; TR; TR-BETA; TR3; TRXR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000383365

InnateDB Gene

IDBG-1472 (TXNRD2)

Protein Structure

UniProt Annotation

Function

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10215850}.

Disease Associations

Tissue Specificity

Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. {ECO:0000269PubMed:10215850, ECO:0000269PubMed:10608886, ECO:0000269PubMed:9923614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0000305	response to oxygen radical
GO:0007507	heart development
GO:0008033	tRNA processing
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000815 Mercuric reductase
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002218 Glucose-inhibited division protein A-related
IPR003953 FAD binding domain
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR006338 Thioredoxin/glutathione reductase selenoprotein
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF01134
PF00890
PF02852
PF07992

PRINTS

PR00945
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NNW7