InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLITRK6

Summary

InnateDB Protein

IDBP-228634.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLITRK6

Protein Name

SLIT and NTRK-like family, member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383143

InnateDB Gene

IDBG-41532 (SLITRK6)

Protein Structure

UniProt Annotation

Function

Regulator of neurite outgrowth required for normal hearing and vision. {ECO:0000269PubMed:23543054}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23543054, ECO:0000269PubMed:23946138}; Single-pass type I membrane protein {ECO:0000269PubMed:23543054, ECO:0000269PubMed:23946138}.

Disease Associations

Deafness and myopia (DFNMYP) [MIM:221200]: An autosomal recessive disorder characterized by prelingual sensorineural hearing loss associated with high myopia. {ECO:0000269PubMed:23543054, ECO:0000269PubMed:23946138}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors. {ECO:0000269PubMed:14557068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001964	startle response
GO:0002088	lens development in camera-type eye
GO:0002093	auditory receptor cell morphogenesis
GO:0007409	axonogenesis
GO:0007416	synapse assembly
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0008344	adult locomotory behavior
GO:0021562	vestibulocochlear nerve development
GO:0031223	auditory behavior
GO:0035264	multicellular organism growth
GO:0042472	inner ear morphogenesis
GO:0043010	camera-type eye development
GO:0048812	neuron projection morphogenesis
GO:0060005	vestibular reflex
GO:0060007	linear vestibuloocular reflex
GO:0060384	innervation
GO:0090102	cochlea development