InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COLEC12

Summary

InnateDB Protein

IDBP-228706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COLEC12

Protein Name

collectin sub-family member 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383115

InnateDB Gene

IDBG-285 (COLEC12)

Protein Structure

UniProt Annotation

Function

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269PubMed:11162630, ECO:0000269PubMed:11564734, ECO:0000269PubMed:12761161, ECO:0000269PubMed:15845541, ECO:0000269PubMed:16868960}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269PubMed:11162630}. Note=Forms clusters on the cell surface.

Disease Associations

Tissue Specificity

Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269PubMed:11162630, ECO:0000269PubMed:11564734, ECO:0000269PubMed:12761161, ECO:0000269PubMed:16868960}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005534	galactose binding
GO:0008329	signaling pattern recognition receptor activity
GO:0030169	low-density lipoprotein particle binding
GO:0046872	metal ion binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0006952	defense response
GO:0006955	immune response
GO:0009756	carbohydrate mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization

Cellular Component

GO:0005581	collagen trimer
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0070062	extracellular vesicular exosome