Version 5.4
Homo sapiens Gene: COLEC12
Summary
InnateDB Gene IDBG-285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COLEC12
Gene Name collectin sub-family member 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158270
Encoded Proteins
IDBP-228706
collectin sub-family member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26290605
Soluble COLEC12 can recognize Aspergillus fumigatus leading to activation of the alternative pathway of complement.
Entrez Gene
Summary This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:319361-500722
Strand Reverse strand
Band p11.32
Transcripts
ENST00000400256 ENSP00000383115
ENST00000582147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005534 galactose binding
GO:0008329 signaling pattern recognition receptor activity
GO:0030169 low-density lipoprotein particle binding
GO:0046872 metal ion binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0006952 defense response
GO:0006955 immune response
GO:0009756 carbohydrate mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0051260 protein homooligomerization
Cellular Component
GO:0005581 collagen trimer
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030666 endocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036103
View Gene Order
ENSBTAG00000007705
Not yet available
Pathways
NETPATH
REACTOME
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_163699
Scavenging by Class A Receptors pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.464422 Hs.620841
RefSeq NM_130386
HUGO
OMIM
CCDS CCDS32782
HPRD 06358
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca