InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FKBP1A

Summary

InnateDB Protein

IDBP-228942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP1A

Protein Name

FK506 binding protein 1A, 12kDa

Synonyms

FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE;

Species

Homo sapiens

Ensembl Protein

ENSP00000383003

InnateDB Gene

IDBG-39495 (FKBP1A)

Protein Structure

UniProt Annotation

Function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269PubMed:16720724, ECO:0000269PubMed:9233797}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0004871	signal transducer activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005515	protein binding
GO:0005527	macrolide binding
GO:0005528	FK506 binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044325	ion channel binding
GO:0046332	SMAD binding
GO:0048185	activin binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0003007	heart morphogenesis
GO:0006457	protein folding
GO:0006458	'de novo' protein folding
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0022417	protein maturation by protein folding
GO:0031398	positive regulation of protein ubiquitination
GO:0032092	positive regulation of protein binding
GO:0032513	negative regulation of protein phosphatase type 2B activity
GO:0032880	regulation of protein localization
GO:0032925	regulation of activin receptor signaling pathway
GO:0042026	protein refolding
GO:0042110	T cell activation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043206	extracellular fibril organization
GO:0050776	regulation of immune response
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347	heart trabecula formation
GO:0061077	chaperone-mediated protein folding
GO:0070588	calcium ion transmembrane transport
GO:1902991	regulation of amyloid precursor protein catabolic process
GO:1990000	amyloid fibril formation

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0014802	terminal cisterna
GO:0016020	membrane
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome