Version 5.4
Homo sapiens Protein: TPTE2
Summary
InnateDB Protein IDBP-229038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPTE2
Protein Name transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382974
InnateDB Gene IDBG-12255 (TPTE2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005216 ion channel activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016311 dephosphorylation
GO:0034220 ion transmembrane transport
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR014020 Tensin phosphatase, C2 domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain
PFAM PF00168
PF00102
PF00782
PF10409
PRINTS PR00360
PR00700
PIRSF
SMART SM00239
SM00194
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6XPS3
PhosphoSite PhosphoSite-Q6XPS3
TrEMBL
UniProt Splice Variant
Entrez Gene 93492
UniGene Hs.377488
RefSeq NP_001258779
HUGO HGNC:17299
OMIM 606791
CCDS CCDS45013
HPRD 06003
IMGT
EMBL AJ421032 AJ421033 AK301741 AL590076 AY219890 BC128146 BC128147 CH471075 FJ969729
GenPept AAI28147 AAI28148 AAP45146 ACT21090 BAG63204 CAD13144 CAD13145 CAH73538 CAH73539 EAX08219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca