InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP16

Summary

InnateDB Protein

IDBP-229311.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP16

Protein Name

ubiquitin specific peptidase 16

Synonyms

UBP-M; UBPM;

Species

Homo sapiens

Ensembl Protein

ENSP00000382857

InnateDB Gene

IDBG-1285 (USP16)

Protein Structure

UniProt Annotation

Function

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. {ECO:0000255HAMAP-Rule:MF_03062, ECO:0000269PubMed:10077596, ECO:0000269PubMed:17914355}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:17914355}.

Disease Associations

Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.

Tissue Specificity

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10077596}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042393	histone binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0016578	histone deubiquitination
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045901	positive regulation of translational elongation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	protein homotetramerization
GO:0070537	histone H2A K63-linked deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02148

PRINTS

PIRSF

SMART

SM00290

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5T5