Version 5.4
Homo sapiens Gene: USP16
Summary
InnateDB Gene IDBG-1285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP16
Gene Name ubiquitin specific peptidase 16
Synonyms UBP-M; UBPM
Species Homo sapiens
Ensembl Gene ENSG00000156256
Encoded Proteins
IDBP-1287
ubiquitin specific peptidase 16
IDBP-229309
ubiquitin specific peptidase 16
IDBP-229311
ubiquitin specific peptidase 16
IDBP-229313
ubiquitin specific peptidase 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:29024629-29054488
Strand Forward strand
Band q21.3
Transcripts
ENST00000334352 ENSP00000334808
ENST00000399976 ENSP00000382858
ENST00000399975 ENSP00000382857
ENST00000399973 ENSP00000382855
ENST00000474835
ENST00000485067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042393 histone binding
GO:0043130 ubiquitin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0016578 histone deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045901 positive regulation of translational elongation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051289 protein homotetramerization
GO:0070537 histone H2A K63-linked deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025616
View Gene Order
ENSBTAG00000020122
Not yet available
Cross-References
SwissProt
TrEMBL H9KVB6
UniProt Splice Variant
Entrez Gene 10600
UniGene Hs.608191 Hs.99819
RefSeq NM_001001992 NM_001032410 NM_006447
HUGO HGNC:12614
OMIM 604735
CCDS CCDS13583 CCDS42912
HPRD 06881
IMGT
EMBL AF129075
GenPept
RNA Seq Atlas 10600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca