Version 5.4
Homo sapiens Protein: ITPA
Summary
InnateDB Protein IDBP-229660.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPA
Protein Name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Synonyms C20orf37; dJ794I6.3; HLC14-06-P;
Species Homo sapiens
Ensembl Protein ENSP00000382732
InnateDB Gene IDBG-46106 (ITPA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
GO:0035870 dITP diphosphatase activity
GO:0036220 ITP diphosphatase activity
GO:0036222 XTP diphosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0009204 deoxyribonucleoside triphosphate catabolic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR002637 Ham1-like protein
IPR029001 Inosine triphosphate pyrophosphatase-like
PFAM PF01725
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BY32
PhosphoSite PhosphoSite-Q9BY32
TrEMBL
UniProt Splice Variant
Entrez Gene 3704
UniGene
RefSeq NP_001254552
HUGO HGNC:6176
OMIM 147520
CCDS CCDS58762
HPRD 08856
IMGT
EMBL AB062127 AF026816 AF063607 AF219116 AL109976 AL121891 BC010138 BI115811 CH471133 EF199841 EF213026
GenPept AAB82608 AAG43165 AAH10138 AAK21848 ABO70316 ABP01354 BAB93459 CAC16798 CAI19399 CAM27676 CAM28311 EAX10541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca