InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFITM2

Summary

InnateDB Protein

IDBP-229715.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFITM2

Protein Name

interferon induced transmembrane protein 2 (1-8D)

Synonyms

1-8D; DSPA2c;

Species

Homo sapiens

Ensembl Protein

ENSP00000382714

InnateDB Gene

IDBG-16199 (IFITM2)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269PubMed:19544527, ECO:0000269PubMed:20064371, ECO:0000269PubMed:20534863, ECO:0000269PubMed:20943977, ECO:0000269PubMed:21177806, ECO:0000269PubMed:21253575, ECO:0000269PubMed:22479637}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006955	immune response
GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0034341	response to interferon-gamma
GO:0035455	response to interferon-alpha
GO:0035456	response to interferon-beta
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway