Version 5.4
Homo sapiens Gene: IFITM2
Summary
InnateDB Gene IDBG-16199.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFITM2
Gene Name interferon induced transmembrane protein 2
Synonyms 1-8D; DSPA2c
Species Homo sapiens
Ensembl Gene ENSG00000185201
Encoded Proteins
IDBP-229715
interferon induced transmembrane protein 2 (1-8D)
IDBP-229725
interferon induced transmembrane protein 2 (1-8D)
IDBP-586614
interferon induced transmembrane protein 2 (1-8D)
IDBP-593949
interferon induced transmembrane protein 2 (1-8D)
IDBP-807138
interferon induced transmembrane protein 2
IDBP-807140
interferon induced transmembrane protein 2
IDBP-807141
interferon induced transmembrane protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20064371
IFITM2 is an antiviral restriction factor that mediates cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting their early replication.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:307631-315272
Strand Forward strand
Band p15.5
Transcripts
ENST00000399817 ENSP00000382714
ENST00000399815 ENSP00000382712
ENST00000533141 ENSP00000434443
ENST00000527146 ENSP00000431850
ENST00000602569 ENSP00000473587
ENST00000616316 ENSP00000484689
ENST00000619184 ENSP00000482256
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006955 immune response
GO:0009607 response to biotic stimulus
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q01629
TrEMBL E9PQN9
UniProt Splice Variant
Entrez Gene 10581
UniGene
RefSeq NM_006435
HUGO HGNC:5413
OMIM 605578
CCDS CCDS41583
HPRD
IMGT
EMBL AC136475 BC009696 CR541874 X57351
GenPept AAH09696 CAA40625 CAG46672
RNA Seq Atlas 10581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca