Version 5.4
Homo sapiens Protein: GPR132
Summary
InnateDB Protein IDBP-22994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR132
Protein Name G protein-coupled receptor 132
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328818
InnateDB Gene IDBG-22992 (GPR132)
Protein Structure
UniProt Annotation
Function May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity. {ECO:0000269PubMed:12586833, ECO:0000269PubMed:19855098, ECO:0000269PubMed:9770487}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. {ECO:0000269PubMed:12482833}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006950 response to stress
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005388 G2A lysophosphatidylcholine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR01563
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UNW8
PhosphoSite PhosphoSite-Q9UNW8
TrEMBL
UniProt Splice Variant
Entrez Gene 29933
UniGene Hs.532504
RefSeq NP_037477
HUGO HGNC:17482
OMIM 606167
CCDS CCDS9997
HPRD 06936
IMGT
EMBL AB465599 AB465600 AF083955 AK292142 AK303654 AL512356 BC004555 BC084546 BT007257 CH471061 EU432121
GenPept AAD47380 AAH84546 AAP35921 ABY87920 BAF84831 BAG64656 BAG84609 BAG84610 EAW81898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca