InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITSN1

Summary

InnateDB Protein

IDBP-230659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITSN1

Protein Name

intersectin 1 (SH3 domain protein)

Synonyms

ITSN; SH3D1A; SH3P17;

Species

Homo sapiens

Ensembl Protein

ENSP00000382275

InnateDB Gene

IDBG-2505 (ITSN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	161 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0032947	protein complex scaffold
GO:0070064	proline-rich region binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048488	synaptic vesicle endocytosis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000261 EPS15 homology (EH)
IPR001452 SH3 domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00018
PF14604
PF00036
PF13202
PF13405
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00027
SM00326
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt