InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCC1

Summary

InnateDB Protein

IDBP-230717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC1

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Synonyms

ABC29; ABCC; GS-X; MRP; MRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000382342

InnateDB Gene

IDBG-16439 (ABCC1)

Protein Structure

UniProt Annotation

Function

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO:0000269PubMed:10064732, ECO:0000269PubMed:11114332, ECO:0000269PubMed:16230346}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16230346}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:16230346}.

Disease Associations

Tissue Specificity

Lung, testis and peripheral blood mononuclear cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006691	leukotriene metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0009235	cobalamin metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005292 Multi drug resistance-associated protein
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33527