InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCC1

Summary

InnateDB Gene

IDBG-16439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC1

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Synonyms

ABC29; ABCC; GS-X; MRP; MRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000103222

Encoded Proteins

IDBP-230717

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

IDBP-230719

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

IDBP-753367

IDBP-748556

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:15949577-16143074

Strand

Forward strand

Band

p13.11

Transcripts

ENST00000399410	ENSP00000382342
ENST00000399408	ENSP00000382340
ENST00000572882	ENSP00000461615
ENST00000572053	ENSP00000459693
ENST00000574224
ENST00000575422
ENST00000574761
ENST00000576557

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006691	leukotriene metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0009235	cobalamin metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome