InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPFFR2

Summary

InnateDB Protein

IDBP-23103.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPFFR2

Protein Name

neuropeptide FF receptor 2

Synonyms

GPR74; HLWAR77; NPFF2; NPGPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000340789

InnateDB Gene

IDBG-23097 (NPFFR2)

Protein Structure

UniProt Annotation

Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas. {ECO:0000269PubMed:10079187}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008188	neuropeptide receptor activity
GO:0031628	opioid receptor binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0009582	detection of abiotic stimulus
GO:0043408	regulation of MAPK cascade
GO:0045761	regulation of adenylate cyclase activity
GO:2000479	regulation of cAMP-dependent protein kinase activity