Version 5.4
Homo sapiens Gene: NPFFR2
Summary
InnateDB Gene IDBG-23097.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPFFR2
Gene Name neuropeptide FF receptor 2
Synonyms GPR74; HLWAR77; NPFF2; NPGPR
Species Homo sapiens
Ensembl Gene ENSG00000056291
Encoded Proteins
IDBP-23099
neuropeptide FF receptor 2
IDBP-23101
neuropeptide FF receptor 2
IDBP-23103
neuropeptide FF receptor 2
IDBP-238408
neuropeptide FF receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:72031804-72148067
Strand Forward strand
Band q13.3
Transcripts
ENST00000308744 ENSP00000307822
ENST00000358749 ENSP00000351599
ENST00000344413 ENSP00000340789
ENST00000395999 ENSP00000379321
ENST00000506359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008188 neuropeptide receptor activity
GO:0031628 opioid receptor binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0009582 detection of abiotic stimulus
GO:0043408 regulation of MAPK cascade
GO:0045761 regulation of adenylate cyclase activity
GO:2000479 regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035528
View Gene Order
ENSBTAG00000009070
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16973
Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.99231
RefSeq NM_001144756 NM_004885 NM_053036
HUGO
OMIM
CCDS CCDS3551 CCDS3552 CCDS47072
HPRD 16244
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca