InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUNX1

Summary

InnateDB Protein

IDBP-231097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX1

Protein Name

runt-related transcription factor 1

Synonyms

AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB;

Species

Homo sapiens

Ensembl Protein

ENSP00000382182

InnateDB Gene

IDBG-2825 (RUNX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	101 [view]
Protein-DNA	19 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005524	ATP binding

Biological Process

GO:0006355

regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain

PFAM

PF00853

PRINTS

PR00967

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A8MZI9

UniProt Splice Variant

Entrez Gene

861

UniGene

Hs.717697

RefSeq

HUGO

HGNC:10471

OMIM

151385

CCDS

HPRD

IMGT

EMBL

AF015262 AF015720 AF015721 AF015722 AF015723 AF015724 AF015725 AF015726 AF020800 AF020801 AF020802 AF020803 AF022141 AF022794 AF027207 AF051934 AF129107 AF129108 AP000330 AP000331 AP000332 AP000333 AP000334 AP000687 AP000688

GenPept