Version 5.4
Homo sapiens Protein: SMTNL1
Summary
InnateDB Protein IDBP-231366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMTNL1
Protein Name smoothelin-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382108
InnateDB Gene IDBG-231364 (SMTNL1)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, myofibril {ECO:0000269PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269PubMed:18310078, ECO:0000269PubMed:20634291}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0045907 positive regulation of vasoconstriction
GO:0045908 negative regulation of vasodilation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031430 M band
GO:0031674 I band
GO:0043292 contractile fiber
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
PFAM PF00307
PF11971
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8MU46
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 219537
UniGene Hs.68756
RefSeq
HUGO HGNC:32394
OMIM 613664
CCDS
HPRD
IMGT
EMBL AP002893
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca