InnateDB Protein
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IDBP-231399.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COL25A1
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Protein Name
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collagen, type XXV, alpha 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000382083
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InnateDB Gene
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IDBG-33750 (COL25A1)
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Protein Structure
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Function |
Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269PubMed:15522881, ECO:0000269PubMed:15615705, ECO:0000269PubMed:15853808, ECO:0000269PubMed:16300410}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269PubMed:11927537}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008160
Collagen triple helix repeat
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PFAM |
PF01391
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXS0
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PhosphoSite |
PhosphoSite-Q9BXS0
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TrEMBL |
D6R8Y2
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UniProt Splice Variant |
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Entrez Gene |
84570
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UniGene |
Hs.658842
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RefSeq |
NP_942014
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HUGO |
HGNC:18603
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OMIM |
610004
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CCDS |
CCDS43258
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HPRD |
09886
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IMGT |
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EMBL |
AC004051
AC004701
AC073427
AC095066
AC097473
AF293340
AF293341
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GenPept |
AAK35008
AAK35009
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