InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL25A1

Summary

InnateDB Protein

IDBP-231405.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL25A1

Protein Name

collagen, type XXV, alpha 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382077

InnateDB Gene

IDBG-33750 (COL25A1)

Protein Structure

UniProt Annotation

Function

Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269PubMed:15522881, ECO:0000269PubMed:15615705, ECO:0000269PubMed:15853808, ECO:0000269PubMed:16300410}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted.

Disease Associations

Tissue Specificity

Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269PubMed:11927537}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0008201	heparin binding

Biological Process

GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane