InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH5

Summary

InnateDB Protein

IDBP-231414.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH5

Protein Name

alkB, alkylation repair homolog 5 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382091

InnateDB Gene

IDBG-33623 (ALKBH5)

Protein Structure

UniProt Annotation

Function

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export and is required for spermatogenesis. {ECO:0000269PubMed:21264265, ECO:0000269PubMed:23177736}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:21264265, ECO:0000269PubMed:23177736}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269PubMed:17979886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0035515	oxidative RNA demethylase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0035553	oxidative single-stranded RNA demethylation