InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAG

Summary

InnateDB Protein

IDBP-23147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAG

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Synonyms

14-3-3GAMMA; PPP1R170;

Species

Homo sapiens

Ensembl Protein

ENSP00000306330

InnateDB Gene

IDBG-23145 (YWHAG)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269PubMed:16511572}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, skeletal muscle, and heart. {ECO:0000269PubMed:10486217}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	347 [view]
Protein-Protein	345 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006469	negative regulation of protein kinase activity
GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0009966	regulation of signal transduction
GO:0045664	regulation of neuron differentiation
GO:0048167	regulation of synaptic plasticity
GO:0061024	membrane organization
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway