InnateDB Protein
|
IDBP-231481.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
POLR3G
|
Protein Name
|
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
|
Synonyms
|
RPC32; RPC7;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000382058
|
InnateDB Gene
|
IDBG-33164 (POLR3G)
|
Protein Structure
|
|
Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269PubMed:19609254, ECO:0000269PubMed:19631370}.
|
Subcellular Localization |
Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
12
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0001056
|
RNA polymerase III activity
|
GO:0003899
|
DNA-directed RNA polymerase activity
|
|
Biological Process |
GO:0006359
|
regulation of transcription from RNA polymerase III promoter
|
GO:0006383
|
transcription from RNA polymerase III promoter
|
GO:0006384
|
transcription initiation from RNA polymerase III promoter
|
GO:0006385
|
transcription elongation from RNA polymerase III promoter
|
GO:0006386
|
termination of RNA polymerase III transcription
|
GO:0008283
|
cell proliferation
|
GO:0010467
|
gene expression
|
GO:0032481
|
positive regulation of type I interferon production
|
GO:0032728
|
positive regulation of interferon-beta production
|
GO:0045087
|
innate immune response
|
GO:0045089
|
positive regulation of innate immune response
|
GO:0051607
|
defense response to virus
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR024661
DNA-directed RNA polymerase III, subunit Rpc31
|
PFAM |
PF11705
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O15318
|
PhosphoSite |
PhosphoSite-O15318
|
TrEMBL |
D6RIT0
|
UniProt Splice Variant |
|
Entrez Gene |
10622
|
UniGene |
Hs.629725
|
RefSeq |
NP_006458
|
HUGO |
HGNC:30075
|
OMIM |
|
CCDS |
CCDS43337
|
HPRD |
17881
|
IMGT |
|
EMBL |
AC027323
AC093510
AK295434
CH471084
U93868
|
GenPept |
AAB63676
BAG58376
EAW95980
EAW95981
EAW95982
|
|
|