InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPT7

Summary

InnateDB Protein

IDBP-231604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT7

Protein Name

septin 7

Synonyms

CDC10; CDC3; NBLA02942; SEPT7A;

Species

Homo sapiens

Ensembl Protein

ENSP00000381992

InnateDB Gene

IDBG-12430 (SEPT7)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. {ECO:0000269PubMed:17803907, ECO:0000269PubMed:18460473}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18460473}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:18460473}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:18460473}. Cleavage furrow {ECO:0000269PubMed:18460473}. Midbody {ECO:0000269PubMed:18460473}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15915442}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	59 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042802	identical protein binding

Biological Process

GO:0000910	cytokinesis
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0016476	regulation of embryonic cell shape
GO:0051291	protein heterooligomerization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0016324	apical plasma membrane
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0043679	axon terminus
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome