InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEPT7

Summary

InnateDB Gene

IDBG-12430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT7

Gene Name

septin 7

Synonyms

CDC10; CDC3; NBLA02942; SEPT7A

Species

Homo sapiens

Ensembl Gene

ENSG00000122545

Encoded Proteins

IDBP-12432

septin 7

IDBP-231602

septin 7

IDBP-231604

septin 7

IDBP-372019

septin 7

IDBP-372049

septin 7

IDBP-602634

septin 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:35800932-35907105

Strand

Forward strand

Band

p14.2

Transcripts

ENST00000350320	ENSP00000344868
ENST00000399035	ENSP00000381993
ENST00000399034	ENSP00000381992
ENST00000435235	ENSP00000413507
ENST00000425198	ENSP00000387913
ENST00000432293	ENSP00000444240
ENST00000493626
ENST00000475109
ENST00000473201
ENST00000492940
ENST00000485569

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	59 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042802	identical protein binding

Biological Process

GO:0000910	cytokinesis
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0016476	regulation of embryonic cell shape
GO:0051291	protein heterooligomerization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0016324	apical plasma membrane
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0043679	axon terminus
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001833

View Gene Order

ENSBTAG00000001182

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.191346 Hs.627519

RefSeq

NM_001011553 NM_001242956 NM_001788

HUGO

OMIM

CCDS

CCDS75582

HPRD

04398

IMGT

EMBL

GenPept

RNA Seq Atlas