InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCRL2

Summary

InnateDB Protein

IDBP-231650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCRL2

Protein Name

chemokine (C-C motif) receptor-like 2

Synonyms

ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR;

Species

Homo sapiens

Ensembl Protein

ENSP00000381994

InnateDB Gene

IDBG-30415 (CCRL2)

Protein Structure

UniProt Annotation

Function

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18397265, ECO:0000269PubMed:20002784}; Multi-pass membrane protein {ECO:0000269PubMed:18397265, ECO:0000269PubMed:20002784}.

Disease Associations

Tissue Specificity

Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269PubMed:11828366, ECO:0000269PubMed:15188357, ECO:0000269PubMed:18397265, ECO:0000269PubMed:9473515}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0042379	chemokine receptor binding
GO:0048020	CCR chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway