Version 5.4
Homo sapiens Gene: CCRL2
Summary
InnateDB Gene IDBG-30415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCRL2
Gene Name chemokine (C-C motif) receptor-like 2
Synonyms ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR
Species Homo sapiens
Ensembl Gene ENSG00000121797
Encoded Proteins
IDBP-30417
chemokine (C-C motif) receptor-like 2
IDBP-227173
chemokine (C-C motif) receptor-like 2
IDBP-227175
chemokine (C-C motif) receptor-like 2
IDBP-231650
chemokine (C-C motif) receptor-like 2
IDBP-374518
chemokine (C-C motif) receptor-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:46407163-46412997
Strand Forward strand
Band p21.31
Transcripts
ENST00000357392 ENSP00000349967
ENST00000400882 ENSP00000383678
ENST00000400880 ENSP00000383677
ENST00000399036 ENSP00000381994
ENST00000433848 ENSP00000414957
ENST00000495870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0042379 chemokine receptor binding
GO:0048020 CCR chemokine receptor binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.535713
RefSeq NM_001130910 NM_003965
HUGO
OMIM
CCDS CCDS43079 CCDS46814
HPRD 16327
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca