InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN11

Summary

InnateDB Protein

IDBP-232221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN11

Protein Name

calpain 11

Synonyms

calpain11;

Species

Homo sapiens

Ensembl Protein

ENSP00000381758

InnateDB Gene

IDBG-89052 (CAPN11)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in testis. {ECO:0000269PubMed:10409436}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0008233	peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR002048 EF-hand domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF00036
PF13202
PF13405
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00054
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt