InnateDB Protein
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IDBP-232331.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2D2
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Protein Name
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ubiquitin-conjugating enzyme E2D 2
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Synonyms
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E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381718
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InnateDB Gene
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IDBG-47921 (UBE2D2)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269PubMed:10329681, ECO:0000269PubMed:15280377, ECO:0000269PubMed:18042044, ECO:0000269PubMed:18359941, ECO:0000269PubMed:18703417, ECO:0000269PubMed:19854139, ECO:0000269PubMed:20061386, ECO:0000269PubMed:20403326, ECO:0000269PubMed:20525694}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
239
[view]
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Protein-Protein |
239
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62837
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PhosphoSite |
PhosphoSite-P62837
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TrEMBL |
D6RFM0
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UniProt Splice Variant |
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Entrez Gene |
7322
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UniGene |
Hs.108332
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RefSeq |
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HUGO |
HGNC:12475
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OMIM |
602962
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CCDS |
CCDS43369
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HPRD |
04268
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IMGT |
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EMBL |
AC010378
AC018797
AF317220
AK001311
AK001428
AY651263
BC033349
CH471062
L40146
U39317
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GenPept |
AAA91460
AAC41750
AAH33349
AAK93958
AAX35690
BAG50891
BAG50911
EAW62095
EAW62096
EAW62097
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