InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2D2

Summary

InnateDB Protein

IDBP-232333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D2

Protein Name

ubiquitin-conjugating enzyme E2D 2

Synonyms

E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B;

Species

Homo sapiens

Ensembl Protein

ENSP00000381717

InnateDB Gene

IDBG-47921 (UBE2D2)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269PubMed:10329681, ECO:0000269PubMed:15280377, ECO:0000269PubMed:18042044, ECO:0000269PubMed:18359941, ECO:0000269PubMed:18703417, ECO:0000269PubMed:19854139, ECO:0000269PubMed:20061386, ECO:0000269PubMed:20403326, ECO:0000269PubMed:20525694}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	239 [view]
Protein-Protein	239 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070936	protein K48-linked ubiquitination
GO:0071456	cellular response to hypoxia