InnateDB Protein
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IDBP-232523.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC38A1
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Protein Name
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solute carrier family 38, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381634
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InnateDB Gene
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IDBG-28524 (SLC38A1)
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Protein Structure
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Function |
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269PubMed:10891391}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:15054072}; Multi-pass membrane protein {ECO:0000269PubMed:15054072}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. {ECO:0000269PubMed:10891391, ECO:0000269PubMed:12388062, ECO:0000269PubMed:15054072, ECO:0000269PubMed:16148032}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005283
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sodium:amino acid symporter activity
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GO:0015175
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neutral amino acid transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013057
Amino acid transporter, transmembrane
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PFAM |
PF01490
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2H9
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PhosphoSite |
PhosphoSite-Q9H2H9
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TrEMBL |
Q8NCD8
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UniProt Splice Variant |
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Entrez Gene |
81539
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UniGene |
Hs.719858
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RefSeq |
NP_109599
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HUGO |
HGNC:13447
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OMIM |
608490
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CCDS |
CCDS41774
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HPRD |
12245
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IMGT |
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EMBL |
AC016254
AC025031
AF247166
AF271070
AK027825
AK074758
AK074797
AK074949
BC010620
CH471111
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GenPept |
AAG39354
AAG44546
AAH10620
BAB55394
BAC11186
BAC11215
BAC11310
EAW57895
EAW57896
EAW57897
EAW57898
EAW57899
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