Version 5.4
Homo sapiens Gene: SLC38A1
Summary
InnateDB Gene IDBG-28524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC38A1
Gene Name solute carrier family 38, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111371
Encoded Proteins
IDBP-232523
solute carrier family 38, member 1
IDBP-373078
solute carrier family 38, member 1
IDBP-597738
solute carrier family 38, member 1
IDBP-590912
solute carrier family 38, member 1
IDBP-583773
solute carrier family 38, member 1
IDBP-590896
solute carrier family 38, member 1
IDBP-808711
solute carrier family 38, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:46183063-46270017
Strand Reverse strand
Band q13.11
Transcripts
ENST00000398637 ENSP00000381634
ENST00000439706 ENSP00000398142
ENST00000549049 ENSP00000449607
ENST00000546893 ENSP00000447853
ENST00000552197 ENSP00000449756
ENST00000548979
ENST00000549633
ENST00000551506
ENST00000550173 ENSP00000449744
ENST00000546519
ENST00000612161 ENSP00000478907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005283 sodium:amino acid symporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0007268 synaptic transmission
GO:0015804 neutral amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023169
View Gene Order
ENSBTAG00000000859
Not yet available
Pathways
NETPATH
REACTOME
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_13639
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_13594
Neurotransmitter uptake and Metabolism In Glial Cells pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H2H9
TrEMBL A0A024R124 F8VX12 Q8NCD8
UniProt Splice Variant
Entrez Gene 81539
UniGene Hs.533770 Hs.719858
RefSeq NM_001278388 NM_001077484 NM_001278387 NM_001278389 NM_001278390 NM_030674
HUGO HGNC:13447
OMIM 608490
CCDS CCDS41774 CCDS61106
HPRD 12245
IMGT
EMBL AC016254 AC025031 AF247166 AF271070 AK027825 AK074758 AK074797 AK074949 BC010620 CH471111
GenPept AAG39354 AAG44546 AAH10620 BAB55394 BAC11186 BAC11215 BAC11310 EAW57895 EAW57896 EAW57897 EAW57898 EAW57899
RNA Seq Atlas 81539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca