InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM2A

Summary

InnateDB Protein

IDBP-232539.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM2A

Protein Name

lysine (K)-specific demethylase 2A

Synonyms

CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA;

Species

Homo sapiens

Ensembl Protein

ENSP00000381640

InnateDB Gene

IDBG-59841 (KDM2A)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {ECO:0000269PubMed:16362057, ECO:0000269PubMed:19001877}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:19001877, ECO:0000269PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269PubMed:10231032}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0051864	histone demethylase activity (H3-K36 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0070544	histone H3-K36 demethylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR002857 Zinc finger, CXXC-type
IPR003347 JmjC domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF02008
PF02373
PF08007
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00558

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y2K7