Version 5.4
| Homo sapiens Gene: KDM2A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-59841.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KDM2A | ||||||||||||||||||
| Gene Name | lysine (K)-specific demethylase 2A | ||||||||||||||||||
| Synonyms | CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000173120 | ||||||||||||||||||
| Encoded Proteins |
lysine (K)-specific demethylase 2A
lysine (K)-specific demethylase 2A
lysine (K)-specific demethylase 2A
lysine (K)-specific demethylase 2A
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:67119269-67258087 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q13.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9Y2K7 | ||||||||||||||||||
| TrEMBL | I3VM53 I3VM54 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 22992 | ||||||||||||||||||
| UniGene | Hs.124147 Hs.622131 | ||||||||||||||||||
| RefSeq | NM_001256405 NM_012308 XM_006718479 XM_006718480 XM_006718481 | ||||||||||||||||||
| HUGO | HGNC:13606 | ||||||||||||||||||
| OMIM | 605657 | ||||||||||||||||||
| CCDS | CCDS44657 CCDS58148 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB023221 AB490246 AF179221 AK024505 AL117517 AP000729 AP001885 BC001203 BC047371 BC047486 BC064360 CH471076 JQ710741 JQ710742 JQ710743 JQ710744 | ||||||||||||||||||
| GenPept | AAD56012 AAH01203 AAH47371 AAH47486 AAH64360 AFK81540 AFK81541 AFK81542 AFK81543 BAA76848 BAB15795 BAJ05817 CAH10721 EAW74578 EAW74580 | ||||||||||||||||||
| RNA Seq Atlas | 22992 | ||||||||||||||||||